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Oscar Delaney

Honours Student

I majored in genetics, maths, and philosophy in my science/arts dual degree at UQ, and then worked on computational modelling of antibiotic resistance evolution, considering recombination, resource constraints and population bottlenecks. Some of the key troubles with this approach are a) the real world isn’t as neat and tidy as our model, and b) even our model is sufficiently big and messy that results can be hard to interpret. However, I think these are surmountable barriers and that computer simulations are an interesting addition to lab and clinical work. And I think coding is pretty fun!

Drug mode of action and resource constraints modulate antimicrobial resistance evolution
Oscar Delaney, Christopher R. P. Brown, Andrew D. Letten, Jan Engelstädter
Journal of Theoretical Biology, 618, 112316 (2026)

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preprint URL

Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ

Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ
Oscar Delaney, Andrew D Letten, Jan Engelstädter
Evolution, 79, 1900--1910 (2025)

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Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation

Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation
Oscar Delaney, Andrew D Letten, Jan Engelstädter
Genetics, 225, iyad185 (2023)

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