Hasan Shimul Chowdhury Mehedi
The evolution of multidrug resistance has limited our current therapeutic options by conferring resistance to virtually all classes of antibiotics currently available for the treatment of infectious diseases. I have extensively worked with molecular epidemiological study of these multidrug resistant bacteria carrying ESBLs and carbapenemases including, NDM-1 as well as VIM metallo-β-lactamase. So far, very little work has been done on the population biology and evolutionary processes that contribute to this multidrug resistance. Therefore, I will study these processes by which multidrug resistance evolve and spread in bacterial populations. To address these questions, I will use the combination of simple evolutionary experiments and mathematical modeling. This study will eventually be an inevitable tool for tracing the evolutionary fate of infectious diseases, especially when these diseases are implicated with multiple drug resistance.
2013- present: PhD student
2011-2012: Research Assistant, Karolinska Institutet, Stockholm, Sweden
2009-2011: MSc in Infection Biology, Uppsala Universitet, Uppsala, Sweden
2002-2007: BSc in Biotechnology and Genetic Engineering, Islamic University, Bangladesh
Titelman E., Hasan, C.M., Iversen, A., Naucler, P., Kais, M., Kalin, M., Giske, C.G.
Faecal carriage of extended-spectrum b-lactamase-producing Enterobacteriaceae is common 12 months after infection and is related to strain factors.
Clinical Microbiology and Infection, in press.
Hasan, C.M., Turlej-Rogacka, A., Vatopoulos, A.C., Giakkoupi, P., Maâtallah, M. & Giske C.G.
Dissemination of blaVIM in Greece at the peak of the epidemic of 2005–2006: clonal expansion of Klebsiella pneumoniae clonal complex 147.
Clinical Microbiology and Infection 20(1):34-7 (2013)
Giske C.G., Fröding I., Hasan C.M., Turlej-Rogacka A., Toleman M., Livermore D., Woodford N. & Walsh T.R.
Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination of blaNDM-1 in India, Sweden, and the United Kingdom
Antimicrobial Agents and Chemotherapy 56(5):2735-8 (2012)